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1), with the warmest observed mean freezing temperature in this study (7.9 0.3 C), including the highest fraction frozen with initial freezing at 6.8 C and complete freezing at 9 C (Fig

Non-neurological features included congenital lactic acidosis, cardiomyopathy, hepatomegaly, kyphoscoliosis, optic atrophy, roving eye movements, strabismus, and distal renal tubular acidosis [55-58,60]

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co-treatment with dexamethasone attenuated these effects and increased the expression of the antioxidant enzyme glutathione peroxidase 3 (GPX3), as revealed via RNA-sequencing