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This is one reason many supplements use racemic mixtures instead, which contain equal parts R- and S-ALA

doi: 10.3390/ijms21030950 92

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Schafer ZT, Grassian AR, Song L, Jiang Z, Gerhart-Hines Z, Irie HY, Gao S, Puigserver P, Brugge JS: Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment