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Fizyolojik olarak glenme u ekilde aklanabilir: GHRH, hipofizin somatotrop hcrelerinde cAMP sinyal yolunu aarken, ghrelin mimetii GHS reseptr zerinden kalsiyum kaynakl ikinci bir sinyal yolunu aktive eder

The logical identification of S 1 and S 2 building blocks led to the discovery of effective DPP-2 inhibitors, which were characterized by their high selectivity for DPP-2 over DPP-4