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Speculation ran wild

Calcium channels have been shown to mediate Mn uptake both in vitro and in vivo , as Mn uptake was enhanced by calcium channel activators and inhibited by blockers ( 2+ -dependent inhibition of choline uptake in rats

Kolbrich EA, Goodwin RS, Gorelick DA, Hayes RJ, Stein EA, Huestis MA (2008) Plasma pharmacokinetics of 3,4-methylenedioxymethamphetamine after controlled oral administration to young adults

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The choice depends on whether glucose control or cardiovascular risk reduction is the higher priority for your specific situation

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