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Research Use and Experimental Protocols In preclinical studies, MT2 is typically administered via injection in animal models, with dosing regimens ranging from microgram to milligram levels, depending on the study design

Administration of 200 mg/kg silymarin also reduced the rotational behavior caused by 6-hydroxydopamine (6-OHDA) in hemi-parkinsonian rats and the substantia nigra pars compacta neurons were protected against its toxicity, suggesting a dose-dependently neuroprotection effect of silymarin against 6-OHDA toxicity, through oxidative stress decline and by means of an estrogenic pathway (52)

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It activates three receptors simultaneously