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At the same time, calcium carbonate nanoparticles loaded with anti-CD47 antibodies encapsulated in fibrin gels and PLGA nanoparticles that encapsulate baicalin and melanoma antigen Hgp peptide fragments and further encapsulate CpG fragments with conjugated M2pep and -pep peptides on the surface all can repolarize tumor-promoting M2 macrophages into tumor-killing M1-type macrophages (56, 62)

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Additionally, fatigue emerged as a frequently discussed symptom, despite being less prominent in clinical trial data