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In-Vitro Research Models: Glutathione is widely used in non-clinical research exploring oxidative damage and cellular protection mechanisms

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The maintenance of Complex I activity suggests that cells may activate alternative pathways or regulatory mechanisms to uphold mitochondrial function under stress conditions, aligning with previous studies on cellular adaptation strategies (Kluckova and Tennant 2018

In contrast, eukaryotic ubiquitin-like specific proteases (ULPs) cleaving SUMO or NEDD8 chains mostly belong to the CE-clan

To overcome this limitation, this study introduces ZFPG nanoparticles (ZFPG NPs) with ZnFe 2 O 4 @Pt cores and glucose oxidase (GOx) shells