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Severe MTHFR deficiency Patients with severe MTHFR deficiency typically have severe hyperhomocystinuria (greater than 100umol/L), hypomethioninemia, decreased circulating folate, decreased CH3-tetrahydrofolate, and decreased neurotransmitters (1)

doi: 10.1053/j.ackd.2014.11.004 38 MatsusakaTNiimuraFShimizuAPastanISaitoAKoboriHet al

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