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If there are concerns about the safety of participants, the independent DSMB will make a recommendation to the trial executive committee regarding continuing, stopping or modifying the trial

If a small number of pathways are consistently dysregulated across these conditions, targeting these pathways could potentially provide symptom relief for a broad spectrum of patients with different diagnoses

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Kaugars GE, Heise AP, Riley WT, Abbey LM, Svirsky JA

Engel H, Krbling M, Palmer J, Mehra R, Walker J, Andreeff M , Champlin R