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Together with folate, cobalamins are essential cofactors required for DNA synthesis in cells where chromosomal replication and division are occurringmost notably the bone marrow and myeloid cells

A slowed metabolism and weight gain can occur for a variety of reasons, such as not eating enough calories, too much cortisol, high insulin levels, or thyroid problems

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Common signs include fatigue, weakness, numbness or tingling in the hands and feet, trouble with balance, or cognitive changes

Sources of Vitamin B12 Animal Foods Vitamin B12 primarily comes from animal-based foods

[1] In practice, 1 mL (which provides the full 100 mg of B and B, etc.) is a common dose for general supplementation in deficient states, but clinicians may start with lower volumes for mild deficiencies or in smaller patients