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Johnson-Rabbett says

241 GLP-1(936) can directly act on pancreatic -cells to inhibit the secretion of glucagon

the reduced lateral diffusion of GLP-1R V229A could therefore be due to the mutant receptor existing as a subpopulation of pre-clustered, higher order oligomeric assemblies in absence of agonist stimulation, predicted to cause a decrease in the movement of these clusters and potentially hinder cholesterol binding

The first person kept their metabolic rate intact