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CJC-1295 without DAC occupies the sweet spot: longer-acting than sermorelin (which degrades too fast for reliable clinical effect), shorter-acting than DAC (which sacrifices pulsatility), and considerably cheaper than tesamorelin (the only FDA-approved option in this class)

A phase 1 trial (synonymous with dose-escalation or human pharmacology studies) is the first instance in which a new investigational agent is studied in humans

Give the system a break so it can normalize

& Gordon, W

Recognition of this phenotype may enable development of dual-pathway targeted therapies (Zhao et al., 2021

These observations reinforce the need for well-designed randomised controlled trials (RCTs) to validate the findings and expand the evidence base