however, this hypothesis has not yet been confirmed
Whereas pharmacotherapeutic and other interventions have steadily improved the prognosis of other types of cardiovascular disease (CVD) and associated sequelae, HF remains associated with more pronounced morbidity and mortality, constituting one of the most pronounced unmet needs in cardiovascular medicine (Shah et al., 2020)
However, tesofensine faces significant challenges - cardiovascular side effects (increased heart rate and blood pressure) raised safety concerns, FDA has not approved it despite promising efficacy data, development stalled after Phase 3 trials, currently available only through research chemical suppliers with questionable legality, and the stimulant-like mechanism creates dependency and tolerance risks not seen with GLP-1 agonists
Health Canada
Assessment of cell differentiation The differentiated C2C12 cells were stained with Crystal Violet Staining Solution (Beyotime, China), and images were taken using an inverted microscope (Nikon ECLIPSE Ti, Japan)
PMID 20616908