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In rare cases individuals inherit a mutation in the GIF gene that encodes intrinsic factor resulting in pernicious anemia

The SURMOUNT trials evaluating tirzepatide for obesity showed weight reductions of 15-21% of body weight over 72 weeks at the highest doses

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The care paradigm is starting to shift, with the understanding that its beneficial to treat metabolic health conditions before they progress to an advanced stage. The team hopes this new data can help physicians better understand and identify patients who are less likely to access obesity treatment, with challenges ranging from difficulty in obtaining care from obesity medicine practitioners to lack of formulary coverage for weight-management medications