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While a few smaller peptides or those with special modifications might have slightly better oral bioavailability, injectable administration remains the gold standard for most peptide research to ensure efficacy.

However, the underlying mechanism is not yet clear

A randomized, double blind, placebo-controlled trial examined the effects of intranasal insulin administration on cognition, function, cerebral glucose metabolism, and cerebrospinal fluid biomarkers in adults with amnestic mild cognitive impairment or Alzheimer disease (AD) [72]

The HGF mimics may be in the form of pharmacuetically acceptable salts, e.g