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The surveillance of abnormal nucleic acids from invading pathogens or damaged cells is conducted by PRRs including RIG-I, melanoma differentiation-associated gene 5 (MDA5), cyclic GMP-AMP synthase (cGAS), and absent in melanoma 2 (AIM2)

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The number and share of LIS enrollees in national PDPs vary considerably, which is related to the fact that only 1 of these 10 plans (Wellcare Classic) is a benchmark PDP in all 34 PDP regions, meaning it is available to all Part D enrollees receiving LIS for no premium (4 other PDPs are benchmark plans in some but not all regions) (Appendix Table 3)

But in this trial, tirzepatide set a very high bar