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[1] Increases in amylase and lipase In trials, tirzepatide-treated patients had a mean increase from baseline in amylase of 20% to 25% and an increase in lipase of 28% to 35%

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Together with mutagenesis and molecular dynamics (MD) simulations, we propose a peptide-binding mechanism previously unseen in GLP-1R and provide a structural basis of enhanced GLP-1R signaling allosterically modulated by LSN3318839