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Chronic heavy drinking (defined as more than 14 drinks per week for men, 7 for women) creates a separate problem: sustained hypothalamic-pituitary-adrenal axis dysregulation

Hyperglycemia modulates M1/M2 macrophage polarization via reactive oxygen species overproduction in ligature-induced periodontitis

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However, maintaining weight loss after stopping medication is a known real-world challenge due to compensatory biological changes 1