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Reduces oxidative stress Glutathione reduces oxidative stress by neutralizing free radicals and can recycle itself back into its active form, allowing for continuous protection of DNA and mitochondria

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In summary, intracellular GSH levels are influenced by several factors: (i) oxidative stress, (ii) conjugation with electrophiles, (iii) export from the cell, (iv) enzymatic reduction of GSSG, and (v) de novo synthesis

In putamen, GPX4 was concentrated within dystrophic dopaminergic axons in Parkinson's subjects, although overall levels of GPX4 were not significantly different compared to control putamen

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