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The authors suggested that environmental factors, such as ambient temperature, may modulate hypothalamic-pituitary-thyroid axis activity, contributing to fluctuations in disease activity or laboratory values in patients with Hashimotos thyroiditis, highlighting the importance of considering the seasonal context in the diagnosis and treatment of thyroid disorders.Finally, living in overly sterile environments with limited exposure to environmental agents has been linked to a higher incidence of HT, possibly due to reduced immune system training and altered microbiota composition (Klubo-Gwiezdzinska And Wartofsky 2022)

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J Hepatol 2022;77:607-18.ArticlePubMed 115

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43 Another study, which compared Caucasian and Chinese populations indicated the increased susceptibility of the former to APAP hepatotoxicity reflects the lower CYP 2E1 and 2D6 activity in the latter