Louis found that GLP-1 medications were associated with lower risks of developing substance use disorders involving alcohol, nicotine, cannabis, cocaine, opioids, and other substances
Unlike earlier medications like semaglutide (Ozempic) and tirzepatide (Mounjaro), retatrutide is designed to act on multiple hormone receptors simultaneouslyincluding GLP-1, GIP, and glucagon receptors
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Each drug Zepbound, Semaglutide GLP-1, Wegovy, and Mounjaro has its strengths
These are not all the possible side effects of Mounjaro
It has Phase 3 REDEFINE-1 data showing about 22.7% weight loss at 68 weeks, and an NDA was filed with FDA in December 2025