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GLP-1 Receptor Agonists: Semaglutide, Tirzepatide, Retatrutide, and Survodutide Glucagon-like peptide-1 (GLP-1) receptor agonists enhance insulin secretion, suppress appetite, and delay gastric emptying, leading to reduced calorie intake and weight loss

Curr Diabetes Rev 10(4):238250

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The hormonal data points in one direction

Furthermore, prostaglandin E2 (PGE2) signaling via EP4 receptors was identified as a critical contributor to Exendin-4s vasodilatory effect, highlighting the involvement of multiple signaling pathways

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