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Skin Pharmacology and Physiology 25(3):141-151. [doi.org]

2005 Dec 11;591(1-2):74-92

We will look at food, stress, and your environment

Unlike earlier broad-spectrum senolytics that can harm healthy tissue, FOXO4-DRI targets a molecular interaction unique to senescent cells

Risk factors for low biotin levels include prolonged antibiotic use, certain genetic conditions affecting biotin metabolism, excessive alcohol consumption, and diets very low in biotin-rich foods

But these findings have not been confirmed in humans