First, we emulated two cardiovascular outcome trials, SUSTAIN-6 (semaglutide versus sitagliptin as placebo proxy) and SURPASS-CVOT (tirzepatide versus dulaglutide), to benchmark and critically evaluate our design, data and analytic framework
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When administering the injection, pinch a fold of skin gently at the chosen site, insert the needle at a 90-degree angle (or 45 degrees if you have very little subcutaneous fat), and press the plunger slowly and steadily
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For a 10mg vial reconstituted with 2mL of bacteriostatic water, the concentration is 5mg/mL