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Given the relatively disappointing outcomes from clinical trials directed towards modulating IGF1R signaling, there is reason to hope that an alternative approach to regulating this network of oncogenic pathways may come from regulating the ligands and their regulatory binding proteins, some of which also act through mechanisms independent of IGF1R signaling

These include diabetes or high blood pressure that is not well managed anticoagulation or bleeding disorder allergies or hypersensitivity to steroid medication or anesthesia infection at the site of the injection congestive heart failure While doctors consider spinal injections generally safe, severe complications may occur in rare cases

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European Journal of Pharmacology, 833, 274289

Asia Pacific Journal of Clinical Nutrition, 17 Suppl 1 , 167-168