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Its discovery originated from studies comparing human plasma from young and older adults, with the younger plasma being more effective in inducing macromolecular synthesis in rat hepatocytes and hepatoma cells [8, 9]

doi: 10.1186/s12964-023-01398-5 219 De AlmeidaAJPODe OliveiraJCPLDa Silva PontesLVDe Souza JniorJFGonalvesTAFDantasSHet al

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[14] Both variants are believed to stem from a strongly protective effect against Plasmodium falciparum and Plasmodium vivax malaria

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But most of what gets written about it stays stuck at the mechanism level: what it might do, what pathways it might touch