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If retatrutide follows the Mounjaro pattern, eligibility is likely to start with adults living with severe obesity (BMI 40+) and several weight-related conditions, then broaden in later cohorts

The doses studied in pivotal trials represent the minimum effective doses required to demonstrate statistically significant and clinically meaningful outcomes in glycaemic control, weight reduction, and cardiovascular risk reduction

Supplementation should generally be reserved for documented deficiencies, as excessive supplementation can cause side effects

A program showing all four is operating as regulators expect

Studies have found that people taking semaglutide GLP-1 lose an average of 15% of their starting body weight, while those on liraglutide typically lose around 5% to 10%

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