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Gut Microbes 12:1801301 Santos LP, Gigante DP, Delpino FM, Maciel AP, Bielemann RM (2022) Sugar sweetened beverages intake and risk of obesity and cardiometabolic diseases in longitudinal studies: a systematic review and meta-analysis with 1.5 million individuals

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Oxidative stress plays a significant role in the pathogenesis of GO and GD (the balance between oxidants and antioxidants is disturbed in favor of ROS), and an antioxidant approach is proposed for treatment (85, 86)

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It is not obvious which hormone or system is more important, as ovarian function can be influenced by systemic GH and IGF, local GH, GH-induced local IGF, and/or GH-independent IGF (48)