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Pre-clinical studies showed that anti-atherogenic effect of GLP-1 is independent of modulation of plasma lipid levels and depends on anti-inflammatory response

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[11] [12] These cardiovascular benefits have influenced treatment algorithms, with guidelines recommending GLP-1 receptor agonists with proven cardiovascular benefit for patients with type 2 diabetes and atherosclerotic cardiovascular disease

Recent studies have pointed out that GLP-1 can increase the expression of ABCA1 and ABCG1 in ApoE -/- mice, thereby reducing the area of aortic plaque in HF raised ApoE -/- mice and realizing the reverse transport of aortic plaque

Avoid taking liraglutide if you have a personal or family history of MTC or MEN 2, as these drugs carry a boxed warning for thyroid C-cell tumors