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Furthermore, with glycogen synthase kinase 3 (GSK3) defined as canonical upstream regulator of -catenin [12], sympathetic nervous system (SNS) has been found to stimulate the Wnt/-catenin signaling pathway in AILI, at least in part via expansion of hepatic progenitor/oval cells, which are both targets and sources of Wnt ligands [110]

10.1016/j.redox.2021.102041 Redox Biol

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Decoding immune resistance in MSS CRC: the role of metabolicimmune crosstalk Immune checkpoint inhibitors (ICIs) have demonstrated significant efficacy in patients with microsatellite instability-high (MSI-H) CRC, yet their therapeutic benefit remains limited in the majority of cases, which are microsatellite stable (MSS) [80]