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Ruling out these important causes, and any hypothalamic lesion, three common diagnostic possibilities remain: the presence of microadenoma, macroadenoma or no visible tumor at all

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The addition of DPP-4 inhibitors to patients already treated with metformin may seem particularly attractive, since both drugs may act to enhance circulating levels of GLP-1 and thus, may have synergistic effects on incretin receptor signaling [44,45,46]