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Analytes were extracted with 15 ml of 1% (v/v) acetic acid in acetonitrile added to the 40 ml tube and shaken on vortex mixer for 1 min

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SAMe processing and 1-carbon cycle The process of generating SAMe involves a bicyclic cellular pathway consisting of folate and methionine cycles, which both belong to the 1-carbon cycle, a metabolic network that integrates nutrients from the environment to yield multiple epigenetic regulatory and biological functions [10]

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