The current gold-standard approach to assess metabolite interactions in such cases is isotopic labeling, which allows the tracking of one or more heavy elemental isotopes through the metabolome with mass spectrometry, nuclear-magnetic resonance, or similar metabolomic techniques (Wang et al., 2024)
Hasanuzzaman M, Al Mahmud J, Nahar K, Anee TI, Inafuku M, Oku H, Fujita M (2017a) Responses, adaptation, and ROS metabolism in plants exposed to waterlogging stress
The review also covered three therapeutic research strategies: direct GSH depletion (leading to ferroptosis or enhanced chemotherapy sensitivity), indirect approaches targeting the tumour microenvironment, and prodrug strategies utilising elevated tumour GSH for drug activation
They are not a replacement for a balanced diet or medical treatment
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