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Create client communication templates for transition announcements now, and understand that marketing materials might not be ready until six months before implementation

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Depression Low motivation, emotional flattening, reduced resilience and poor recovery from stress may occur when inflammation and energy demand remain high

Such trials should incorporate comprehensive, patient-centered outcomes, including local tumor control, overall survival, acute and late toxicity, quality of life, sexual function, and fertility preservation, ensuring that clinical benefits are balanced against potential risks