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Only 36 % were female

D., Fang, Y., & Yang, S

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Sleep and stress management : Poor sleep can contribute to increased oxidative stress

Furthermore, in human reviews 3 of muscle protein metabolism, activation of IGF-1/Akt/mTOR signaling directly correlated with higher protein synthesis rates and improved muscle density, particularly in response to resistance training and nutrient intake

Heart rate effects peak around week 24 of treatment and then decline at weeks 36 and 48 even with continued dosing