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This individual variation makes close monitoring essential during the first 46 weeks of treatment

10.1152/jn.00230.2011 132

Missing doses or inconsistent timing can result in suboptimal glucose control and reduced therapeutic benefit

J Neurosurg Pediatr 19:538545 Bellarbi S, Harmouch A, El Ochi MR, Fikri M, Arkha Y, Sefiani S (2013) Melanotic progonoma of temporal and occipital bones: a case report