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Long Noncoding RNA ZFAS1 Silencing Alleviates Rheumatoid Arthritis via Blocking miR-296-5p-Mediated Down-Regulation of MMP-15

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It upregulates the expression of early growth response protein 1 (EGR-1), a transcription factor that controls over 30 downstream genes involved in cytokine production, growth factor signaling, and extracellular matrix remodeling