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Though further research is underway on the MTHFR gene, its been suggested that those with this gene mutation resulting in hyperhomocysteinemia may experience issues with: Inflammation Memory Immunity Migraines Depression Cognition Sleep By restoring some of the common vitamin/nutrient deficiencies seen in this condition, homocysteine levels may begin to decrease, resulting in an improvement in some of these symptoms

10.1038/s41598-020-68056-5 19 ChiuM

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Furthermore, such heterotypic interactions do not necessitate classical -sheet-rich amyloid fibril formation, but rather favor amorphous, lipidrich, and membranedense inclusions