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By reducing NNMT activity, the bodys ability to break down fat and generate cellular energy is restored

Groups switched from WD to LD had a greater average relative abundance of Verrucomicrobia (represented solely by the genus Akkermansia )

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medRxiv 2026, IQVIA PharMetrics cohort (n=20,504 non-diabetic weight-loss users), incident allodynia 35 vs 15 per 1,000 person-years against bupropion-naltrexone, adjusted HR 2.15 (95% CI 1.572.96)