How Trulicity works Trulicity mimics one hormone called GLP-1 (glucagon-like peptide-1), which: Slows food movement through your stomach, helping you feel fuller for longer Communicates with your brains appetite centre to reduce hunger Improves blood sugar control by enhancing insulin function How Mounjaro works Mounjaro activates two hormone receptors: Like Trulicity, it activates the GLP-1 receptor It also activates GIP (glucose-dependent insulinotropic polypeptide), a second gut hormone involved in appetite and blood sugar regulation This dual-action is the primary reason Mounjaro produces greater weight loss and blood sugar improvements than GLP-1-only medications like Trulicity
The Long R3 modification prevents it from binding to IGF-binding proteins, allowing it to remain active in the body for a longer duration
The peptides will be reviewed by the Pharmacy Compounding Advisory Committee (PCAC), with consideration scheduled for the meeting on 2324 July 2026 or by February 2027
Additionally, most drugs require specialized drug development and design to ensure they are small enough and have a high enough lipid solubility to effectively cross the BBB for the treatment of central nervous system diseases
Safe for human use
ROC analysis showed high diagnostic sensitivity (96.7%) and low specificity (53.3%) for GDF15 at a cutoff of 478.31 pg/mL (AUC = 0.922, 95% CI: 0.8750.969, p 0.05)
