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Strikingly, these favorable features conferred by QMP were independent of the presence of a C-terminal L585

In research settings,

Even if the amount of GLP-1 produced from probiotic-stimulated L cells is modest in terms of systemic blood levels, local activation of vagal afferents in the gut could still transmit meaningful satiety signals to the brain

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The 8mg dose produced 22.8% average weight loss at 48 weeks in the phase 2 trial, with 100% of participants losing at least 5% and 91% losing at least 10% of body weight