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For patients who cannot tolerate GLP-1 RAs or SGLT2 inhibitors or face cost and coverage barriers, sitagliptin provides a safe alternative that avoids harm, even if it does not reduce events to the same degree as newer drugs

Pyroptosis plays a role in containing infections and promoting immune clearance, but excessive or dysregulated pyroptosis has also been implicated in the pathogenesis of sterile inflammatory and autoimmune diseases

Why take that gamble when there are established, well-researched options available

Weight loss, particularly when gradual, can improve insulin sensitivity and help stabilize hormones like testosterone and estrogen

Evaluate weight loss at 16 weeks

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