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Unlike native IGF-1, IGF-1 LR3s structural tweaks confer a three- to five-fold longer half-life and increased receptor binding , making it uniquely suited for sustained signaling experiments

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However, the large size of the therapeutic molecule restricts its access to tumour cells, particularly in central regions of solid tumours (Russell et al, 1992)

[DOI] [PMC free article] [PubMed] [Google Scholar] 112.Atwood KC, Woockner E, Baratz RS, Sampson WI

Nail involvement in alopecia areata (AA) Up to 66% of patients with AA may present nail signs