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Compound 33 exhibited XO inhibitory activity similar to that of febuxostat, with IC 50 values of 12 and 10 nM respectively (Figure 12)

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Lilly's flagship products, Mounjaro and Zepbound, alone brought in more than $36 billion in 2025, and its chief executive has estimated that 20 to 25 million patients are now taking the two companies' medicines

Reducing the dosage of clozapine or slowing titration could reverse cardiac side effects