Because of how vitamin B12 is absorbed, the most common risk factors for B12 deficiency are: Genetic susceptibility : Some people genetically produce less intrinsic factor and stomach acid needed for B12 absorption
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At standard concentrations (topical serums at 0.1-1%, injections at 1-4 mg daily), copper peptides deliver copper well below toxic thresholds
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Vegetarians and Vegans Since B12 is primarily found in animal products, vegetarians and vegans are at a higher risk of deficiency