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et al.'s study investigating the effects of lamotrigine, an antiepileptic, on vasospasm in a rabbit experimental SAH model 25

Third, and most fundamentally, each ingredient does something in isolation is not evidence that the mixture does the sum of those somethings in a living system

While the baseline FS% of the dogs in the EPIC trial were calculated before administration of pimobendan began, no minimum or maximum FS% was a criterion in selecting or excluding the dogs for the trial, and there is no indication from the final report that any subsequent FS% measurements were taken