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On October 4, 2016, Alnylam Pharmaceuticals terminated revusiran, its RNAi therapeutic for Transthyretin amyloidosis with cardiomyopathy, following 19 patient fatalities in a phase 3 trial,, 17 in the treatment cohort compared to 2 in the placebo group,, resulting in a $3.6 billion decline in market capitalization and investor doubt regarding the RNAi platform

Gallbladder events rise modestly, especially with rapid loss. Less common signals include skin dysesthesia, which is now on the label, and a small thyroid-cancer association in two population studies with a tiny absolute event rate. Depression and suicidality remain unproven

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