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Acknowledgements This work was supported by the National Science and Technology Council, Taiwan (grant number NSTC 111-2320-B-002-037-MY3 to F-JL) and National Taiwan University (grant numbers 110L7243, 111L7218, and 113L894803 to F-JL)

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Disulphide bond integrity: Uniquely important for this compound, the disulphide bond between Cys-7 and Cys-15 must be correctly formed

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His team sees this pattern often: someone on metformin for insulin resistance, PCOS, or type 2 diabetes, who assumed the exhaustion was just part of trying to lose weight