glutathione and nadph Pathways disulfide reductase Mini MCAT passage: Pentose phosphate

Venturella G et al

Therefore, we decided to knock out the genes encoding NAD + -dependent glutamate dehydrogenase ( GDH2 ) and NADPH-dependent glutamate dehydrogenase ( GDH3 ) in order to assess the role of the cells redox balance and nitrogen metabolism in C

In the Danish Prospective Diet, Cancer, and Health prospective study that followed over 57,000 men and women for 14 years, the risk of rectal cancer was found to be 42% higher in current smokers compared to nonsmokers

The implication is that theyre roughly the same kind of thing and youre choosing between them

Treatment Resistance: High GSH levels confer significant resistance to anticancer drugs and radiation, as cancer cells use GSH to neutralize these therapies

10.1038/cr.2017.133 190 ZhaoC.SunG.LiY.KongK.LiX.KanT.et al (2023)