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27 Importantly, meta-analyses suggest that patients with lean MASLD may have a higher all-cause mortality rate than those with nonlean MASLD (hazard ratio 1.61, 95% confidence interval 1.371.89), independent of traditional risk factors

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Safety and efficacy of a GLP-1 and glucagon receptor dual agonist mazdutide (IBI362) 9 mg and 10 mg in Chinese adults with overweight or obesity: A randomised, placebo-controlled, multiple-ascending-dose phase 1b trial Ji L, Jiang H, An P, et al

Isoprenaline-induced lesions appeared due to damaging free radical induction [29]

The additional pathway appears to provide meaningful incremental benefit